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CS-W001157 4
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Cycloheptanamine

  • CAS No. 5452-35-7

  • Cat. No. CS-0071927
  • Purity≥97%
  • MDL No.MFCD00004153

*For research and further manufacturing use only, not for direct human use.

Cycloheptanamine|CS-0071927

Structure of 5452-35-7

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General Information

  • CAS No. 5452-35-7
  • Cat. No. CS-0071927
  • Purity ≥97%
  • MDL No. MFCD00004153
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅N
  • Molecular Weight 113.20
  • Synonym(s) Cycloheptylamine
  • SMILES NC1CCCCCC1

Description

Cycloheptanamine delivers a rigid, nitrogen-containing seven-membered ring ideal for probing conformational effects in medicinal chemistry. This bench-stable scaffold integrates readily into bioactive molecules, offering enhanced metabolic resilience and predictable spatial orientation in target engagement studies.

Application

Cycloheptanamine serves as a valuable scaffold in medicinal chemistry, offering a rigid, nitrogen-containing seven-membered ring ideal for probing bioactive conformational space. Its amine functionality enables straightforward derivatization via alkylation, acylation, or reductive amination, while demonstrating good bench stability and compatibility with common protecting groups. This compound functions effectively as a building block in the synthesis of heterocyclic APIs and receptor-targeted small molecules.

Synthesis

  • Route1
    • Cycloheptanone oxime|CS-0449588
      2158-31-8
    • ~%
    • In-stock
      Cycloheptanamine|CS-0071927
      5452-35-7

    References

    • Journal of the American Chemical Society, , vol. 75, p. 3215,3217
  • Route2
    • null|null
      502-42-1
    • ~89%
    • In-stock
      Cycloheptanamine|CS-0071927
      5452-35-7

    References

    • Miriyala, Bruhaspathy; Bhattacharyya, Sukanta; Williamson, John S. Tetrahedron, 2004 , vol. 60, # 7 p. 1463 - 1471
  • Route3
    • null|null
      33670-51-8
    • ~81%
    • In-stock
      Cycloheptanamine|CS-0071927
      5452-35-7

    References

    • Salunkhe, Ashok M.; Veeraraghavan Ramachandran; Brown, Herbert C. Tetrahedron, 2002 , vol. 58, # 50 p. 10059 - 10064

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 2734
Class : 8 (3)
Packing Group : Ⅱ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.6679
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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