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CS-W001157 4
Total: USD 88.00

6-Hydroxy-3,4-dihydroquinolin-2(1H)-one

  • CAS No. 54197-66-9

  • Cat. No. CS-W002905
  • Purity≥98%
  • MDL No.MFCD02179410

*For research and further manufacturing use only, not for direct human use.

6-Hydroxy-3,4-dihydroquinolin-2(1H)-one|CS-W002905

Structure of 54197-66-9

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General Information

  • CAS No. 54197-66-9
  • Cat. No. CS-W002905
  • Purity ≥98%
  • MDL No. MFCD02179410
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO₂
  • Molecular Weight 163.18
  • Synonym(s) 6-Hydroxyl-3.4-dihydro-2-(1H)-quinolinone
  • SMILES O=C1NC2=C(C=C(O)C=C2)CC1

Description

Lactosyl () C12 Ceramide is suitable as an internal standard:to determine if the isopropanol is a choice procedure for large-scale lipid profiling using UHPLC-MSto assess the effects of diabetes and the treatment with dihydroprogesterone (DHP) in rat cerebral cortexin the lipidomic analysis of extracellular vesicles (EVs) released by human fibroblasts undergoing Oncogene-Induced Senescence (OIS)

Application

6-Hydroxy-3,4-dihydroquinolin-2(1H)-one serves as a versatile scaffold for heterocyclic synthesis, enabling efficient access to bioactive molecules through established functionalization at the C6 hydroxyl and lactam carbonyl sites. Its bench-stable nature and compatibility with standard coupling, oxidation, and cyclization protocols make it a practical building block in medicinal chemistry workflows.

Synthesis

  • Route1
    • 3-Chloro-N-(4-hydroxyphenyl)propanamide|CS-0157450
      19314-10-4
    • ~87%
    • In-stock
      6-Hydroxy-3,4-dihydroquinolin-2(1H)-one|CS-W002905
      54197-66-9

    References

    • Pfizer Products Inc. Patent: EP1175417 B1, 2004 ; Location in patent: Page 27 ;
  • Route2
    • null|null
      7446-70-0
    • In-stock
      3-Chloro-N-(4-methoxyphenyl)propanamide|CS-0073759
      19313-87-2
    • ~91%
    • In-stock
      6-Hydroxy-3,4-dihydroquinolin-2(1H)-one|CS-W002905
      54197-66-9

    References

    • Mendelovici, Marioara; Pilarsky, Gideon; Nidam, Tamar; Dolitzky, Ben-Zion Patent: US2002/32333 A1, 2002 ;
  • Route3
    • null|null
      77248-69-2
    • ~75%
    • In-stock
      6-Hydroxy-3,4-dihydroquinolin-2(1H)-one|CS-W002905
      54197-66-9

    References

    • Dinesh, Bhima Reddy; Baba, A. Ramesha; Sankar, K. Udaya; Gowda, D. Channe Journal of Chemical Research, 2008 , # 5 p. 287 - 288

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   1.2769
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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