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CS-W001157 4
Total: USD 88.00

3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride

  • CAS No. 5409-58-5

  • Cat. No. CS-B0837
  • Purity≥98%
  • MDL No.MFCD00554996

*For research and further manufacturing use only, not for direct human use.

3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride|CS-B0837

Structure of 5409-58-5

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General Information

  • CAS No. 5409-58-5
  • Cat. No. CS-B0837
  • Purity ≥98%
  • MDL No. MFCD00554996
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₈ClNO
  • Molecular Weight 263.76
  • Synonym(s) None
  • SMILES O=C(C1=C2C=CC=CC2=CC=C1)CCN(C)C.Cl

Description

This naphthalene-based ketone features a dimethylamino group at the β-position, enhancing electron density and solubility in polar solvents. The hydrochloride salt form ensures improved stability and crystallinity for handling. Designed for use in synthetic organic chemistry and pharmaceutical intermediates, it integrates readily into complex molecular architectures under standard conditions.

Application

3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride serves as a versatile β-keto amine building block, enabling efficient access to substituted quinoline and isoquinoline scaffolds via cyclization reactions. The dimethylamino group enhances nucleophilicity for electrophilic substitution, while the naphthyl moiety provides a rigid, planar framework suitable for conjugated systems. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows requiring functional group compatibility and moderate reactivity.

Synthesis

  • Route1
    • In-stock
      1-Acetylnaphthalene|CS-W020048
      941-98-0
    • null|null
      50-00-0
    • null|null
      506-59-2
    • ~%
    • In-stock
      3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride|CS-B0837
      5409-58-5

    References

    • PROSIDION LIMITED Patent: WO2006/85118 A2, 2006 ; Location in patent: Page/Page column 38 ; WO 2006/085118 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   3.396
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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