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CS-W001157 4
Total: USD 88.00

Idoxuridine

  • CAS No. 54-42-2

  • Cat. No. CS-2346
  • Purity≥98%
  • MDL No.MFCD00134656

*For research and further manufacturing use only, not for direct human use.

Idoxuridine|CS-2346

Structure of 54-42-2

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General Information

  • CAS No. 54-42-2
  • Cat. No. CS-2346
  • Purity ≥98%
  • MDL No. MFCD00134656
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁IN₂O₅
  • Molecular Weight 354.10
  • Synonym(s) 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd
  • SMILES O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(I)C1=O

Description

0

Application

Idoxuridine serves as a thymidine analog with established utility in nucleoside chemistry and antiviral research. Its iodinated pyrimidine base enables site-specific radiolabeling and facilitates incorporation into DNA for probing replication dynamics. The compound exhibits robust bench stability and compatibility with standard phosphorylation protocols, making it a reliable building block for synthetic oligonucleotide studies and mechanistic investigations of viral polymerases.

Synthesis

  • Route1

    References

    • Journal of Molecular Catalysis B: Enzymatic, , vol. 95, p. 16 - 22
  • Route2

    References

    • Kumar; Wiebe; Knaus Canadian Journal of Chemistry, 1994 , vol. 72, # 9 p. 2005 - 2010
  • Route3
    • ((2R,3S,5R)-3-Acetoxy-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate|CS-0196936
      1956-30-5
    • ~92%
    • In-stock
      Idoxuridine|CS-2346
      54-42-2

    References

    • Asakura, Jun-ichi; Robins, Morris J. Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335-H341-H361
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   104.55
  • LogP   -1.2181
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   2

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