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CS-W001157 4
Total: USD 88.00

2-Amino-6-fluorophenol

  • CAS No. 53981-25-2

  • Cat. No. CS-W003533
  • Purity≥95%
  • MDL No.MFCD08532465

*For research and further manufacturing use only, not for direct human use.

2-Amino-6-fluorophenol|CS-W003533

Structure of 53981-25-2

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General Information

  • CAS No. 53981-25-2
  • Cat. No. CS-W003533
  • Purity ≥95%
  • MDL No. MFCD08532465
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) 3-Fluoro-2-hydroxyaniline
  • SMILES FC1=C(O)C(N)=CC=C1

Description

2-Amino-6-fluorophenol features a strategically positioned fluorine atom and amino group on the aromatic ring, enabling precise electronic modulation in synthetic intermediates. This bench-stable compound integrates readily into pharmaceutical scaffolds and functional materials, offering enhanced solubility and reactivity under standard conditions.

Application

2-Amino-6-fluorophenol serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-amino and hydroxyl groups offer complementary reactivity for electrophilic substitution, coupling reactions, and cyclization processes. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic sequences in API development.

Synthesis

  • Route1

    References

    • Rodgers, James D.; Shepard, Stacey; Arvanitis, Argyrios G.; Wang, Haisheng; Storace, Louis; Folmer, Beverly; Shao, Lixin; Zhu, Wenyu; Glenn, Joseph Patent: US2010/298334 A1, 2010 ; Location in patent: Page/Page column 46 ; US 20100298334 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.1135
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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