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CS-W001157 4
Total: USD 88.00

2-(Methylamino)pyrimidine-5-carboxylic acid

  • CAS No. 5388-21-6

  • Cat. No. CS-0045745
  • Purity≥96%
  • MDL No.MFCD08146593

*For research and further manufacturing use only, not for direct human use.

2-(Methylamino)pyrimidine-5-carboxylic acid|CS-0045745

Structure of 5388-21-6

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General Information

  • CAS No. 5388-21-6
  • Cat. No. CS-0045745
  • Purity ≥96%
  • MDL No. MFCD08146593
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇N₃O₂
  • Molecular Weight 153.14
  • Synonym(s) 5-Pyrimidinecarboxylic acid, 2-(methylamino)- (7CI,8CI,9CI)
  • SMILES O=C(C1=CN=C(NC)N=C1)O

Description

2-(Methylamino)pyrimidine-5-carboxylic acid features a pyrimidine core functionalized with a methylamino group at the 2-position and a carboxylic acid at the 5-position. This bifunctional scaffold integrates electron-rich amine and polar carboxylate moieties, enabling versatile conjugation in medicinal chemistry and materials synthesis. The molecule exhibits enhanced solubility and stability under standard conditions, facilitating its use in peptide coupling and heterocyclic derivatization workflows.

Application

2-(Methylamino)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrimidine-based heterocycles relevant to kinase inhibitors and antiviral agents. The molecule combines a readily functionalizable carboxylic acid with a methylamino-substituted pyrimidine core, offering excellent stability, compatibility with standard coupling reactions, and favorable purification profiles in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.11
  • LogP   0.2165
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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