H-D-Pro-OBzl.HCl

Name: H-D-Pro-OBzl.HCl
Brand: ChemScene
Availability: InStock
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CAS No. 53843-90-6
Cat. No. CS-W012788
Molecule weight241.72
Purity≥96%
MDL No.MFCD00153458

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 53843-90-6
Cat. No. CS-W012788
Purity ≥96%
MDL No. MFCD00153458
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₆ClNO₂
Molecular Weight 241.72
Synonym(s) H-D-Pro-OBzl·HCl
SMILES O=C(OCC1=CC=CC=C1)[C@@H]2NCCC2.[H]Cl

Description

H-D-Pro-OBzl.HCl is a bench-stable, moisture-tolerant amino acid derivative featuring a protected D-proline residue with a benzyl ester group. This configuration enables straightforward incorporation into peptide synthesis workflows, offering enhanced solubility and compatibility in aqueous-organic mixtures during chain elongation.

Application

H-D-Pro-OBzl·HCl serves as a stable, bench-ready building block for peptide synthesis, enabling efficient incorporation of D-proline residues with orthogonal protection. The Bzl group provides robust protection of the amine, readily removable under standard hydrogenolysis conditions. Its compatibility with diverse coupling protocols and high purity facilitate reliable access to complex peptide architectures and heterocyclic scaffolds in medicinal chemistry campaigns.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.33
LogP 1.9036
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids C-ProtectedAmino Acids

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H-D-Pro-OBzl.HCl

CAS No. 53843-90-6

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