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CS-W001157 4
Total: USD 88.00

6-Methyl-2,3-pyridinedicarboxylic acid

  • CAS No. 53636-70-7

  • Cat. No. CS-W004504
  • Purity≥98%
  • MDL No.MFCD00075289

*For research and further manufacturing use only, not for direct human use.

6-Methyl-2,3-pyridinedicarboxylic acid|CS-W004504

Structure of 53636-70-7

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General Information

  • CAS No. 53636-70-7
  • Cat. No. CS-W004504
  • Purity ≥98%
  • MDL No. MFCD00075289
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NO₄
  • Molecular Weight 181.15
  • Synonym(s) 6-METHYLQUINOLIC ACID
  • SMILES O=C(C1=NC(C)=CC=C1C(O)=O)O

Description

6-Methyl-2,3-pyridinedicarboxylic acid features a sterically accessible pyridine core with two carboxylic acid groups flanking a methyl substituent at the 6-position. This arrangement enables direct coordination in metal-organic frameworks and facilitates derivatization under mild conditions. The molecule exhibits enhanced solubility in polar solvents compared to unsubstituted analogs, supporting use in aqueous-based synthesis and purification workflows.

Application

6-Methyl-2,3-pyridinedicarboxylic acid serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of bioactive heterocycles and functionalized pyridine derivatives. Its ortho-dicarboxylic acid motif facilitates efficient metal chelation, amidation, and cyclization reactions, while the methyl group provides a handle for further functionalization. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthetic routes and API intermediate development.

Synthesis

  • Route1
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      91-63-4
    • ~%
    • In-stock
      6-Methyl-2,3-pyridinedicarboxylic acid|CS-W004504
      53636-70-7

    References

    • Synthesis, , # 11 p. 880 - 882
  • Route2

    References

    • Journal of the Chemical Society, , p. 4433,4437
  • Route3
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      91-63-4
    • null|null
      7664-93-9
    • null|null
      7732-18-5
    • null|null
      7697-37-2
    • ~%
    • In-stock
      6-Methyl-2,3-pyridinedicarboxylic acid|CS-W004504
      53636-70-7

    References

    • US2513099 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   87.49
  • LogP   0.78642
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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