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CS-W001157 4
Total: USD 88.00

1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

  • CAS No. 534602-47-6

  • Cat. No. CS-W003532
  • Purity≥96%
  • MDL No.MFCD08461329

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid|CS-W003532

Structure of 534602-47-6

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General Information

  • CAS No. 534602-47-6
  • Cat. No. CS-W003532
  • Purity ≥96%
  • MDL No. MFCD08461329
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight None
  • Synonym(s) 1-N-Boc-3-Methyl-Piperidine-3-Carboxylic Acid
  • SMILES O=C(N1CCCC(C1)(C)C(=O)O)OC(C)(C)C

Description

This piperidine derivative features a tert-butoxycarbonyl-protected amine and a methyl-substituted carboxylic acid, enabling direct incorporation into peptide synthesis workflows. The protected nitrogen facilitates efficient coupling reactions under standard conditions, while the sterically hindered methyl group enhances metabolic stability in bioactive molecule design.

Application

1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds with defined stereochemistry. The Boc-protected amine and carboxylic acid functionality offer orthogonal reactivity for peptide coupling and subsequent deprotection. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient access to complex heterocyclic architectures in API development.

Synthesis

  • Route1

    References

    • US2007/82900 A1, ; Page/Page column 158 ; US 20070082900 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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