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CS-W001157 4
Total: USD 88.00

7,8-Dihydro-5(6H)-quinolinone

  • CAS No. 53400-41-2

  • Cat. No. CS-0006841
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7,8-Dihydro-5(6H)-quinolinone|CS-0006841

Structure of 53400-41-2

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General Information

  • CAS No. 53400-41-2
  • Cat. No. CS-0006841
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight 147.17
  • Synonym(s) 7,8-Dihydroquinolin-5(6H)-one
  • SMILES O=C1C2=C(N=CC=C2)CCC1

Description

7,8-Dihydro-5(6H)-quinolinone is a bench-stable heterocyclic scaffold featuring a partially saturated quinoline core. This electron-rich system integrates readily into synthetic routes requiring flexible nitrogen-containing intermediates. Its stable, moisture-tolerant structure supports reliable use in medicinal chemistry and materials development workflows.

Application

7,8-Dihydro-5(6H)-quinolinone serves as a versatile scaffold in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard functionalization at the C4 and C7 positions. Its stable, partially saturated core exhibits excellent compatibility with common coupling reactions and protecting group strategies, facilitating rapid derivatization for lead optimization. The compound functions as a reliable building block in synthetic routes targeting pharmacologically relevant quinoline derivatives.

Synthesis

  • Route1

    References

    • Synthetic Communications, , vol. 28, # 7 p. 1197 - 1200
  • Route2

    References

    • Synthetic Communications, , vol. 28, # 7 p. 1197 - 1200
  • Route3
    • null|null
      624-67-9
    • In-stock
      3-Amino-2-cyclohexen-1-one|CS-0032855
      5220-49-5
    • ~55%
    • In-stock
      7,8-Dihydro-5(6H)-quinolinone|CS-0006841
      53400-41-2

    References

    • Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2736 - 2746

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.6006
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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