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CS-W001157 4
Total: USD 88.00

2-(Bromomethyl)isoindoline-1,3-dione

  • CAS No. 5332-26-3

  • Cat. No. CS-0063420
  • Purity≥95%
  • MDL No.MFCD00005897

*For research and further manufacturing use only, not for direct human use.

2-(Bromomethyl)isoindoline-1,3-dione|CS-0063420

Structure of 5332-26-3

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General Information

  • CAS No. 5332-26-3
  • Cat. No. CS-0063420
  • Purity ≥95%
  • MDL No. MFCD00005897
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrNO₂
  • Molecular Weight 240.06
  • Synonym(s) PHTHALIMIDOMETHYL BROMIDE
  • SMILES O=C1N(CBr)C(C2=C1C=CC=C2)=O

Description

N-(Bromomethyl)phthalimide was used as initiator in synthesis of -phthalimidopoly(styrene) by atom transfer radical polymerisation. It was also used in synthesis of functionalized 5-(aminomethyl)pyrimidine-2,4,6-trione analog and new bis-C(cage)-substituted o-carborane.

Application

2-(Bromomethyl)isoindoline-1,3-dione serves as a versatile synthetic intermediate for constructing heterocyclic scaffolds and functionalizing complex molecules. The bromomethyl group enables efficient nucleophilic substitution reactions, facilitating the introduction of diverse side chains under mild conditions. Its bench-stable nature and compatibility with common protecting groups make it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Tetrahedron Letters, , vol. 33, # 1 p. 77 - 80
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 109, # 22 p. 6758 - 6764
  • Route3
    • null|null
      136918-14-4
    • ~90%
    • In-stock
      2-(Bromomethyl)isoindoline-1,3-dione|CS-0063420
      5332-26-3

    References

    • Chinese Chemical Letters, , vol. 22, # 10 p. 1159 - 1162

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   1.635
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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