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CS-W001157 4
Total: USD 88.00

Benzyl hydrazinecarboxylate

  • CAS No. 5331-43-1

  • Cat. No. CS-W016057
  • Purity≥98%
  • MDL No.MFCD00041890

*For research and further manufacturing use only, not for direct human use.

Benzyl hydrazinecarboxylate|CS-W016057

Structure of 5331-43-1

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General Information

  • CAS No. 5331-43-1
  • Cat. No. CS-W016057
  • Purity ≥98%
  • MDL No. MFCD00041890
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) N-Cbz-hydrazine
  • SMILES NNC(OCC1=CC=CC=C1)=O

Description

Benzyl hydrazinecarboxylate serves as a stable, bench-ready synthon for constructing hydrazide and triazole scaffolds. Featuring a benzyl-protected hydrazine moiety, it enables direct coupling with carboxylic acids or activated esters under mild conditions. The compound's compatibility with diverse reaction media streamlines access to functionalized heterocycles in medicinal chemistry workflows.

Application

Benzyl hydrazinecarboxylate serves as a versatile synthon in heterocyclic synthesis, enabling efficient access to pyrazole and triazole scaffolds via cyclization with carbonyl compounds or alkynes. Its bench-stable nature and compatibility with diverse functional groups facilitate straightforward purification and integration into multi-step sequences. The benzyl ester moiety provides orthogonal protection and convenient deprotection under mild conditions, enhancing its utility in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • Benzyl 1H-imidazole-1-carboxylate|CS-0906671
      22129-07-3
    • ~95%
    • In-stock
      Benzyl hydrazinecarboxylate|CS-W016057
      5331-43-1

    References

    • Gao, Yaojun; Lam, Yulin Journal of Combinatorial Chemistry, 2010 , vol. 12, # 1 p. 69 - 74
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 74, p. 470,473
  • Route3
    • null|null
      501-53-1
    • ~80%
    • In-stock
      Benzyl hydrazinecarboxylate|CS-W016057
      5331-43-1

    References

    • Merkley; Warkentin Canadian Journal of Chemistry, 2000 , vol. 78, # 7 p. 942 - 949

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   0.7865
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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