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CS-W001157 4
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D-Desthiobiotin

  • CAS No. 533-48-2

  • Cat. No. CS-0098609
  • Purity≥97%
  • MDL No.MFCD00213804

*For research and further manufacturing use only, not for direct human use.

D-Desthiobiotin|CS-0098609

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General Information

  • CAS No. 533-48-2
  • Cat. No. CS-0098609
  • Purity ≥97%
  • MDL No. MFCD00213804
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈N₂O₃
  • Molecular Weight 214.26
  • Synonym(s) Dethiobiotin
  • SMILES O=C(O)CCCCC[C@H]([C@H](C)N1)NC1=O

Description

D-Desthiobiotin (CAS 533-48-2) enables high-affinity, reversible protein capture in affinity chromatography through selective streptavidin binding, facilitating purification and detection workflows.

Application

d-Desthiobiotin (CAS 533-48-2) elutes target proteins from streptavidin resin during coimmunoprecipitation by disrupting biotin-streptavidin interactions with high specificity. It enables gentle, efficient recovery of fragile complexes. Researchers leverage this to isolate human Cdc45–MCM–GINS helicase and purify KIF3A/B–KAP3 bound to the APCARM domain.

Synthesis

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    • In-stock
      D-Desthiobiotin|CS-0098609
      533-48-2

    References

    • Journal of the American Chemical Society, , vol. 66, p. 1422
  • Route2

    References

    • Agricultural and Biological Chemistry, , vol. 49, # 9 p. 2783 - 2786

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.43
  • LogP   1.0914
  • H_Acceptors   2
  • H_Donors   3
  • Rotatable_Bonds   6

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