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Structure of 53250-83-2
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2-Chloro-4-(methylsulfonyl)benzoic acid features a strategically positioned chloro group and a robust methylsulfonyl moiety that enhance electrophilic reactivity and metabolic stability. This electron-withdrawing combination enables efficient coupling in late-stage functionalization, particularly in pharmaceutical scaffold elaboration. The carboxylic acid handle supports direct derivatization or salt formation for improved solubility.
2-Chloro-4-(methylsulfonyl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles and pharmaceutical scaffolds. Its orthogonal functional groups—electrophilic chlorine and strongly electron-withdrawing methylsulfonyl—facilitate directed derivatization via nucleophilic aromatic substitution or coupling reactions. The carboxylic acid group supports direct amidation or esterification, while the compound exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: