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CS-W001157 4
Total: USD 88.00

Pirfenidone

  • CAS No. 53179-13-8

  • Cat. No. CS-2905
  • Molecule weight185.22
  • Purity≥98%
  • MDL No.MFCD00866047

*For research and further manufacturing use only, not for direct human use.

Pirfenidone|CS-2905

Structure of 53179-13-8

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General Information

  • CAS No. 53179-13-8
  • Cat. No. CS-2905
  • Purity ≥98%
  • MDL No. MFCD00866047
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁NO
  • Molecular Weight 185.22
  • Synonym(s) AMR69
  • SMILES O=C1C=CC(C)=CN1C2=CC=CC=C2

Description

Standard building block for introduction of aminohexanoic amino-acid residues by Fmoc SPPS Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPS

Application

Pirfenidone serves as a clinically validated antifibrotic agent, functioning as a small-molecule modulator of multiple profibrotic pathways. Its structure features a substituted pyridine core enabling stable interactions with key signaling nodes in fibrosis progression. The compound demonstrates robust bench stability and favorable solubility profiles, facilitating consistent performance in in vitro screening and preclinical model development. It functions as a well-characterized scaffold for mechanistic studies of extracellular matrix remodeling and is routinely employed in research targeting idiopathic pulmonary fibrosis and related connective tissue disorders.

Synthesis

  • Route1

    References

    • AUSPEX PHARMACEUTICALS, INC.; ZHANG, Chengzhi; SOMMERS, Andreas Patent: WO2012/122165 A2, 2012 ; Location in patent: Page/Page column 62 ;
  • Route2
    • null|null
      108-86-1
    • In-stock
      5-Methylpyridin-2(1H)-one|CS-W011282
      1003-68-5
    • ~%
    • In-stock
      Pirfenidone|CS-2905
      53179-13-8

    References

    • WO2010/141600 A2, ; Page/Page column 13-14 ;
  • Route3
    • null|null
      104-92-7
    • In-stock
      4-Methylpyridin-2-ol|CS-W017769
      13466-41-6
    • ~%
    • In-stock
      Pirfenidone|CS-2905
      53179-13-8

    References

    • US2008/161361 A1, ; Page/Page column 8-9 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22
  • LogP   2.14592
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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