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8-Methoxyl-2-tetralone

  • CAS No. 5309-19-3

  • Cat. No. CS-0000109
  • Purity≥95%
  • MDL No.MFCD06411220

*For research and further manufacturing use only, not for direct human use.

8-Methoxyl-2-tetralone|CS-0000109

Structure of 5309-19-3

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General Information

  • CAS No. 5309-19-3
  • Cat. No. CS-0000109
  • Purity ≥95%
  • MDL No. MFCD06411220
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₂
  • Molecular Weight 176.21
  • Synonym(s) 8-methoxy-3,4-dihydronaphthalen-2(1H)-one
  • SMILES O=C1CC(C(OC)=CC=C2)=C2CC1

Description

8-Methoxyl-2-tetralone is a sterically defined, bench-stable ketone featuring a fused bicyclic core with a methoxy group at the 8-position. This electron-donating substituent enhances solubility and modulates reactivity in synthetic transformations. The compound serves as a key intermediate in the construction of complex heterocycles and natural product analogs, particularly in medicinal chemistry campaigns targeting CNS-active scaffolds.

Synthesis

  • Route1
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      843652-67-5
    • ~58%
    • In-stock
      8-Methoxyl-2-tetralone|CS-0000109
      5309-19-3

    References

    • WYETH Patent: WO2005/12291 A1, 2005 ; Location in patent: Page/Page column 76 ; WO 2005/012291 A1
  • Route2

    References

    • Journal of the Chemical Society, , p. 409,416
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    References

    • Eli Lilly and Company Patent: US5026707 A1, 1991 ; US 5026707 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.753
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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