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CS-W001157 4
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(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid

  • CAS No. 52950-18-2

  • Cat. No. CS-W016881
  • Molecule weight186.59
  • Purity≥98%
  • MDL No.MFCD00798429

*For research and further manufacturing use only, not for direct human use.

(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid|CS-W016881

Structure of 52950-18-2

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General Information

  • CAS No. 52950-18-2
  • Cat. No. CS-W016881
  • Purity ≥98%
  • MDL No. MFCD00798429
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClO₃
  • Molecular Weight 186.59
  • Synonym(s) R-2-Chloromandelic Acid
  • SMILES O=C(O)[C@H](O)C1=CC=CC=C1Cl

Description

(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid is a chiral alpha-hydroxy acid featuring a chlorinated aromatic ring and a stereodefined hydroxyl group. This configuration enables precise integration into asymmetric synthesis pathways, particularly in the construction of biologically active compounds. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions, facilitating its use in medicinal chemistry and catalyst design.

Application

(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid serves as a valuable chiral building block for the synthesis of pharmaceutical intermediates and bioactive heterocycles. Its defined stereochemistry and carboxylic acid functionality enable direct use in amide coupling, esterification, and enantioselective transformations. The molecule exhibits good bench stability and facilitates purification via crystallization, supporting scalable synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H317-H318
Precautionary Statements : P261-P272-P280-P302+P352-P363-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.458
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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