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CS-W001157 4
Total: USD 88.00

2-(4-Iodophenyl)ethanol

  • CAS No. 52914-23-5

  • Cat. No. CS-W004990
  • Purity≥97%
  • MDL No.MFCD00173705

*For research and further manufacturing use only, not for direct human use.

2-(4-Iodophenyl)ethanol|CS-W004990

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General Information

  • CAS No. 52914-23-5
  • Cat. No. CS-W004990
  • Purity ≥97%
  • MDL No. MFCD00173705
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉IO
  • Molecular Weight 248.06
  • Synonym(s) p-Iodophenethyl alcohol
  • SMILES C1=CC(=CC=C1CCO)I

Description

2-(4-Iodophenyl)ethanol is a bench-stable, moisture-tolerant building block featuring a terminal hydroxyl group flanked by an aromatic iodide. This combination enables direct functionalization in cross-coupling reactions and facilitates downstream derivatization in medicinal chemistry and materials synthesis.

Application

2-(4-Iodophenyl)ethanol serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki and Stille reactions due to its stable aryl iodide functionality. The primary alcohol group facilitates straightforward derivatization via esterification or ether formation, while the molecule exhibits excellent bench stability and compatibility with standard purification techniques. Its well-defined reactivity profile makes it a reliable intermediate for constructing complex pharmaceutical scaffolds and functionalized aromatics.

Synthesis

  • Route1

    References

    • Miyajima, Daigo; Araoka, Fumito; Takezoe, Hideo; Kim, Jungeun; Kato, Kenichi; Takata, Masaki; Aida, Takuzo Angewandte Chemie - International Edition, 2011 , vol. 50, # 34 p. 7865 - 7869
  • Route2

    References

    • Journal of the Chemical Society, , p. 652,657 Journal of the Chemical Society, , p. 1819
  • Route3

    References

    • Zdobinsky, Tino; Sankar Maiti, Pradipta; Klajn, Rafal Journal of the American Chemical Society, 2014 , vol. 136, # 7 p. 2711 - 2714

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.826
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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