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CS-W001157 4
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3,5-Dimethyl-1H-pyrazol-4-amine

  • CAS No. 5272-86-6

  • Cat. No. CS-0453349
  • Purity≥98%
  • MDL No.MFCD00187666

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethyl-1H-pyrazol-4-amine|CS-0453349

Structure of 5272-86-6

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General Information

  • CAS No. 5272-86-6
  • Cat. No. CS-0453349
  • Purity ≥98%
  • MDL No. MFCD00187666
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃
  • Molecular Weight 111.15
  • Synonym(s) 4-Amino-3,5-dimethylpyrazole
  • SMILES CC1=C(C(=NN1)C)N

Description

3,5-Dimethyl-1H-pyrazol-4-amine features a pyrazole core with methyl groups at the 3 and 5 positions, enhancing steric protection and electronic stability. This bench-stable heterocycle integrates readily into medicinal chemistry scaffolds, offering improved metabolic resilience in bioactive compounds.

Application

3,5-Dimethyl-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrazole-based heterocycles through standard coupling and functionalization reactions. Its bench-stable nature and tolerance to common reaction conditions facilitate straightforward purification and integration into diverse molecular architectures, including kinase inhibitors and bioactive scaffolds.

Synthesis

  • Route1

    References

    • Govor, Evgen V.; Lysenko, Andrey B.; Quinonero, David; Rusanov, Eduard B.; Chernega, Alexander N.; Moellmer, Jens; Staudt, Reiner; Krautscheid, Harald; Frontera, Antonio; Domasevitch, Konstantin V. Chemical Communications, 2011 , vol. 47, # 6 p. 1764 - 1766
  • Route2
    • null|null
      1122-04-9
    • ~49%
    • In-stock
      3,5-Dimethyl-1H-pyrazol-4-amine|CS-0453349
      5272-86-6

    References

    • Pace, Andrea; Buscemi, Silvestre; Vivona, Nicolo; Caronna, Tullio Heterocycles, 2000 , vol. 53, # 1 p. 183 - 190
  • Route3
    • null|null
      3656-05-1
    • ~%
    • In-stock
      3,5-Dimethyl-1H-pyrazol-4-amine|CS-0453349
      5272-86-6

    References

    • Kaymakcioglu, Bedia Kocyigit; Rollas, Sevim; Koercegez, Eylem; Aricioglu, Feyza European Journal of Pharmaceutical Sciences, 2005 , vol. 26, # 1 p. 97 - 103

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.60874
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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