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(S)-2-amino-3-(4-chloro-1H-indol-3-yl)propanoic acid

  • CAS No. 52448-14-3

  • Cat. No. CS-0504807
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD06797630

*For research and further manufacturing use only, not for direct human use.

(S)-2-amino-3-(4-chloro-1H-indol-3-yl)propanoic acid|CS-0504807

Structure of 52448-14-3

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General Information

  • CAS No. 52448-14-3
  • Cat. No. CS-0504807
  • Purity ≥97%
  • MDL No. MFCD06797630
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁ClN₂O₂
  • Molecular Weight None
  • Synonym(s) 4-Chloro-l-tryptophan
  • SMILES N[C@@H](CC1=CNC2=C1C(Cl)=CC=C2)C(=O)O

Description

This chiral amino acid features a 4-chloroindole side chain, offering enhanced hydrophobicity and electron density for applications in peptide synthesis. Designed for efficient incorporation into bioactive sequences, it enables precise structural tuning in drug discovery and chemical biology workflows.

Application

(S)-2-Amino-3-(4-chloro-1H-indol-3-yl)propanoic acid serves as a key chiral building block for indole-containing peptide analogs and bioactive heterocycles. Its well-defined stereochemistry and stable functional groups enable reliable incorporation into synthetic sequences, facilitating efficient coupling reactions and orthogonal protection strategies. This compound functions as a validated scaffold in medicinal chemistry campaigns targeting CNS-modulating agents and kinase inhibitors.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   79.11
  • LogP   1.7757
  • H_Acceptors   2
  • H_Donors   3
  • Rotatable_Bonds   3

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