Boc-D-Met-OH

Name: Boc-D-Met-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 5241-66-7
Cat. No. CS-W004098
Purity≥95%
MDL No.MFCD00038256

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 5241-66-7

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General Information

CAS No. 5241-66-7
Cat. No. CS-W004098
Purity ≥95%
MDL No. MFCD00038256
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉NO₄S
Molecular Weight 249.33
Synonym(s) None
SMILES CSCC[C@H](C(=O)O)NC(=O)OC(C)(C)C

Description

Boc-D-Met-OH serves as a protected derivative of D-methionine, enabling direct incorporation into peptide chains without side-chain interference. The tert-butoxycarbonyl group ensures stability during synthesis and facilitates selective deprotection under mild acidic conditions. This residue integrates cleanly into diverse peptide architectures, particularly where stereochemical integrity and metabolic resistance are critical.

Application

Boc-D-Met-OH serves as a protected D-methionine building block for peptide synthesis, enabling selective incorporation of D-Met residues with high stability and ease of deprotection. The tert-butoxycarbonyl (Boc) group offers robust protection under acidic conditions, while the thioether side chain provides functional group tolerance in standard coupling protocols. Its bench-stable solid form facilitates handling and purification, making it well-suited for both manual and automated synthetic workflows in medicinal chemistry and peptide library development.

Synthesis

Route1
- In-stock
  
  348-67-4
- In-stock
  
  24424-99-5
- ~97%
- In-stock
  
  5241-66-7
References
- Merck and Co., Inc. Patent: US4863953 A1, 1989 ;
Route2
- In-stock
  
  348-67-4
- ~%
- In-stock
  
  5241-66-7
References
- Lyons, Anthony Q.; Pettit, Leslie D. Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 2305 - 2308

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 1.7174
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 5

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Methionine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Boc-D-Met-OH

CAS No. 5241-66-7

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