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CS-W001157 4
Total: USD 88.00

N-Hydroxyphthalimide

  • CAS No. 524-38-9

  • Cat. No. CS-W008848
  • Purity≥97%
  • MDL No.MFCD00005891

*For research and further manufacturing use only, not for direct human use.

N-Hydroxyphthalimide|CS-W008848

Structure of 524-38-9

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General Information

  • CAS No. 524-38-9
  • Cat. No. CS-W008848
  • Purity ≥97%
  • MDL No. MFCD00005891
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅NO₃
  • Molecular Weight 163.13
  • Synonym(s) None
  • SMILES O=C1C2=C(C(N1O)=O)C=CC=C2

Application

N-Hydroxyphthalimide serves as a reliable precursor for nitrenoid transfer reactions, enabling efficient C–H amination and aziridination under mild conditions. Its bench-stable solid form facilitates handling and reproducible execution in synthetic workflows. The molecule functions as a key reagent in transition-metal-catalyzed transformations, offering high functional group tolerance and compatibility with diverse substrates. Widely used in heterocycle synthesis and late-stage functionalization, it provides a practical route to nitrogen-containing scaffolds relevant to medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      85-44-9
    • ~96%
    • In-stock
      N-Hydroxyphthalimide|CS-W008848
      524-38-9

    References

    • Ranadive, V. B.; Khadilkar, B. M.; Samant, S. D. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, p. 1175 - 1177
  • Route2
    • null|null
      150220-29-4
    • ~92%
    • In-stock
      N-Hydroxyphthalimide|CS-W008848
      524-38-9

    References

    • Einhorn; Marcadal-Abbadi Synthetic Communications, 2001 , vol. 31, # 5 p. 741 - 748
  • Route3
    • 2-(Benzyloxy)isoindoline-1,3-dione|CS-0779638
      16653-19-3
    • ~45%
    • In-stock
      N-Hydroxyphthalimide|CS-W008848
      524-38-9

    References

    • Tanaka; Matsuo; Nakanishi; Kataoka; Takase; Otsuki Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 7 p. 2323 - 2330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   0.6718
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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