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CS-W001157 4
Total: USD 88.00

1,3-Bis(3-(dimethylamino)propyl)urea

  • CAS No. 52338-87-1

  • Cat. No. CS-0151252
  • Molecule weight230.35
  • Purity≥97%
  • MDL No.MFCD18970150

*For research and further manufacturing use only, not for direct human use.

1,3-Bis(3-(dimethylamino)propyl)urea|CS-0151252

Structure of 52338-87-1

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General Information

  • CAS No. 52338-87-1
  • Cat. No. CS-0151252
  • Purity ≥97%
  • MDL No. MFCD18970150
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₆N₄O
  • Molecular Weight 230.35
  • Synonym(s) Urea, N,N'-bis(3-(dimethylamino)propyl)-
  • SMILES CN(CCCNC(NCCCN(C)C)=O)C

Description

1,3-Bis(3-(dimethylamino)propyl)urea features a bis-urea scaffold flanked by tertiary amine-functionalized alkyl chains, delivering enhanced solubility and nucleophilicity. This structure enables efficient coordination in catalytic systems and facilitates phase-transfer behavior, supporting applications in synthetic transformations under mild conditions.

Application

1,3-Bis(3-(dimethylamino)propyl)urea serves as a versatile bifunctional amine scaffold with enhanced solubility and nucleophilicity, enabling efficient coupling in peptide synthesis and polymer functionalization. Its tertiary amine groups facilitate protonation and phase-transfer catalysis, while the urea linkage offers hydrogen-bonding capacity and structural rigidity. The molecule exhibits excellent bench stability and ease of purification, making it well-suited for use in multi-step synthetic sequences requiring robust, non-toxic reagents.

Synthesis

  • Route1
    • null|null
      109-55-7
    • In-stock
      Urea|CS-B1800
      57-13-6
    • ~%
    • null|null
      31506-43-1
    • In-stock
      1,3-Bis(3-(dimethylamino)propyl)urea|CS-0151252
      52338-87-1

    References

    • Tosoh Corporation; KISO, Hiroyuki; SUZUKI, Takao; TAKAHASHI, Yoshihiro Patent: EP2657237 A1, 2013 ; Location in patent: Paragraph 0149; 0150 ;
  • Route2
    • null|null
      109-55-7
    • In-stock
      Urea|CS-B1800
      57-13-6
    • ~66%
    • In-stock
      1,3-Bis(3-(dimethylamino)propyl)urea|CS-0151252
      52338-87-1

    References

    • Hoffmann, Sascha; Justus, Eugen; Ratajski, Michal; Lork, Enno; Gabel, Detlef Journal of Organometallic Chemistry, 2005 , vol. 690, # 11 p. 2757 - 2760
  • Route3
    • Diallyl dicarbonate|CS-0318773
      115491-93-5
    • null|null
      109-55-7
    • ~59%
    • In-stock
      1,3-Bis(3-(dimethylamino)propyl)urea|CS-0151252
      52338-87-1
    • null|null
      24579-76-8

    References

    • Sennyey, Gerard; Barcelo, Gerard; Senet,Jean-Pierre Tetrahedron Letters, 1987 , vol. 28, # 47 p. 5809 - 5810

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.61
  • LogP   0.189
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   8

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