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CS-W001157 4
Total: USD 88.00

3,4-Dimethoxy-3-cyclobutene-1,2-dione

  • CAS No. 5222-73-1

  • Cat. No. CS-W005055
  • Purity≥98%
  • MDL No.MFCD00101316

*For research and further manufacturing use only, not for direct human use.

3,4-Dimethoxy-3-cyclobutene-1,2-dione|CS-W005055

Structure of 5222-73-1

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General Information

  • CAS No. 5222-73-1
  • Cat. No. CS-W005055
  • Purity ≥98%
  • MDL No. MFCD00101316
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆O₄
  • Molecular Weight 142.11
  • Synonym(s) Squaric Acid Dimethyl Ester
  • SMILES COC1=C(OC)C(=O)C1=O

Description

m-PEG3-S-PEG1-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self-coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions.

Synthesis

  • Route1
    • null|null
      122-51-0
    • In-stock
      NSC 624671|CS-W019969
      2892-51-5
    • ~%
    • In-stock
      3,4-Dimethoxy-3-cyclobutene-1,2-dione|CS-W005055
      5222-73-1

    References

    • SCHERING CORPORATION Patent: WO2009/5801 A1, 2009 ; Location in patent: Page/Page column 30-31 ;
  • Route2
    • In-stock
      NSC 624671|CS-W019969
      2892-51-5
    • null|null
      149-73-5
    • ~85%
    • In-stock
      3,4-Dimethoxy-3-cyclobutene-1,2-dione|CS-W005055
      5222-73-1

    References

    • Mohamed, Mubina; Goncalves, Theo P.; Whitby, Richard J.; Sneddon, Helen F.; Harrowven, David C. Chemistry - A European Journal, 2011 , vol. 17, # 49 p. 13698 - 13705
  • Route3
    • null|null
      80-11-5
    • In-stock
      NSC 624671|CS-W019969
      2892-51-5
    • ~65%
    • In-stock
      3,4-Dimethoxy-3-cyclobutene-1,2-dione|CS-W005055
      5222-73-1

    References

    • Miles, D.Howard; Payne, Matthew Tetrahedron, 2001 , vol. 57, # 27 p. 5769 - 5772

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H317-H334
Precautionary Statements : P261-P272-P280-P285-P302+P352-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   -0.7002
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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