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CS-W001157 4
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6-Methoxy-2-methylpyridin-3-amine

  • CAS No. 52090-56-9

  • Cat. No. CS-W022506
  • Purity≥98%
  • MDL No.MFCD03095090

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-2-methylpyridin-3-amine|CS-W022506

Structure of 52090-56-9

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General Information

  • CAS No. 52090-56-9
  • Cat. No. CS-W022506
  • Purity ≥98%
  • MDL No. MFCD03095090
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 3-Pyridinamine,6-methoxy-2-methyl-
  • SMILES NC1=CC=C(N=C1C)OC

Description

6-Methoxy-2-methylpyridin-3-amine features a pyridine core functionalized with methoxy and methyl groups at the 6- and 2-positions, respectively, and an amine at the 3-position. This electron-rich scaffold integrates readily into pharmaceutical intermediates, offering enhanced solubility and stability under standard conditions. The para-amino group enables direct coupling reactions, while the flanking substituents modulate electronic properties and steric profile for tailored reactivity in medicinal chemistry applications.

Application

6-Methoxy-2-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its pyridine core supports diverse functionalization, while the methoxy and amino groups offer complementary sites for coupling reactions and derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for modular synthesis workflows in API development and target-oriented compound libraries.

Synthesis

  • Route1

    References

    • WO2004/62665 A1, ; Page/Page column 45 ; WO 2004/062665 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.98082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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