4-Chloro-5-methylpyrimidine

Name: 4-Chloro-5-methylpyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 51957-32-5
Cat. No. CS-W004974
Purity≥97%
MDL No.MFCD08236809

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 51957-32-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 51957-32-5
Cat. No. CS-W004974
Purity ≥97%
MDL No. MFCD08236809
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂
Molecular Weight 128.56
Synonym(s) 4-Chlor-5-methylpyrimidin
SMILES ClC1=NC=NC=C1C

Description

4-Chloro-5-methylpyrimidine serves as a key heterocyclic building block in medicinal chemistry, offering a reactive chlorine site and a methyl group positioned for selective functionalization. This electron-deficient pyrimidine scaffold integrates readily into pharmaceutical intermediates, enabling efficient access to bioactive molecules through cross-coupling and nucleophilic substitution reactions under standard conditions.

Application

4-Chloro-5-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its electron-deficient pyrimidine core exhibits excellent compatibility with nucleophiles and facilitates the construction of biologically relevant heterocyclic scaffolds. The methyl group provides a handle for further derivatization, while the chloro substituent ensures high reactivity under standard coupling conditions. Bench-stable and readily purified, it functions reliably in multi-step syntheses targeting kinase inhibitors and other pharmaceutical candidates.

Synthesis

Route1
- In-stock
  
  17758-52-0
- ~%
- In-stock
  
  51957-32-5
References
- Vanderhaeghe; Claesen Bulletin des Societes Chimiques Belges, 1957 , vol. 66, p. 276,289

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 25.78
LogP 1.43842
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

4-Chloro-5-methylpyrimidine sigma4-Chloro-5-methylpyrimidine manufacturer4-Chloro-5-methylpyrimidine price4-Chloro-5-methylpyrimidine structure4-Chloro-5-methylpyrimidine SDSbuy 4-Chloro-5-methylpyrimidine4-Chloro-5-methylpyrimidine supplier4-Chloro-5-methylpyrimidine uses4-Chloro-5-methylpyrimidine molecular weightprice of 4-Chloro-5-methylpyrimidine4-Chloro-5-methylpyrimidine chemical name formula of 4-Chloro-5-methylpyrimidine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-5-methylpyrimidine

CAS No. 51957-32-5

Recommended Products