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Structure of 51907-18-7
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5H-Cyclopenta[c]pyridin-7(6H)-one is a rigid, electron-deficient heterocycle featuring a fused bicyclic core with a lactam-like carbonyl. This scaffold integrates seamlessly into medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant small molecules. The planar structure enhances π-stacking interactions, while the amide-like functionality enables hydrogen bonding in protein-ligand interfaces.
5H-Cyclopenta[c]pyridin-7(6H)-one serves as a versatile heterocyclic building block in medicinal chemistry, offering a rigid, planar scaffold with defined hydrogen-bonding capacity via its carbonyl and NH functionalities. Its stability under standard reaction conditions enables direct functionalization at the 3- and 5-positions, facilitating access to diverse analogs through palladium-catalyzed cross-couplings and electrophilic substitutions. The core structure functions as a key motif in kinase inhibitor development and other bioactive molecule architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: