Lot numbers can be found on the outside label of a product:
DAO-IN-1
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CAS No. 51856-25-8
- Cat. No. CS-0093690
- Purity≥97%
- MDL No.MFCD02664526
*For research and further manufacturing use only, not for direct human use.
Structure of 51856-25-8
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General Information
- CAS No. 51856-25-8
- Cat. No. CS-0093690
- Purity ≥97%
- MDL No. MFCD02664526
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅NO₂S
- Molecular Weight 167.19
- Synonym(s) None
- SMILES O=C(C1=CC(C=CS2)=C2N1)O
Description
DAO-IN-1 is a potent, selective inhibitor of the enzyme D-amino acid oxidase (DAO), designed to modulate D-amino acid metabolism in neurological and metabolic research. This compound exhibits high specificity and stability under physiological conditions, enabling precise interrogation of DAO-dependent pathways in cellular and in vivo models.
Application
DAO-IN-1 serves as a potent and selective inhibitor of dimethylarginine dimoxygenase (DDO), enabling targeted modulation of asymmetric dimethylarginine (ADMA) levels in biological systems. Its well-defined structure facilitates reliable use in biochemical assays and cellular studies, supporting research into nitric oxide pathway regulation. The compound exhibits favorable bench stability and compatibility with standard purification methods, making it a practical tool for mechanistic investigations in vascular biology and metabolic disease research.
Synthesis
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Route1
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In-stock
![Ethyl 6H-thieno[2,3-b]pyrrole-5-carboxylate|CS-0151719](https://file.chemscene.com/productPIC/CS-0151719.gif)
35357-56-3 - ~100%
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In-stock
51856-25-8
References
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Keio University Patent: EP2022794 A1, 2009 ; Location in patent: Page/Page column 18; 19 ;
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Route2
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In-stock
498-62-4 - ~%
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In-stock
51856-25-8
References
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Venable, Jennifer D.; Cai, Hui; Chai, Wenying; Dvorak, Curt A.; Grice, Cheryl A.; Jablonowski, Jill A.; Shah, Chandra R.; Kwok, Annette K.; Ly, Kiev S.; Pio, Barbara; Wei, Jianmei; Desai, Pragnya J.; Jiang, Wen; Nguyen, Steven; Ling, Ping; Wilson, Sandy J.; Dunford, Paul J.; Thurmond, Robin L.; Lovenberg, Timothy W.; Karlsson, Lars; Carruthers, Nicholas I.; Edwards, James P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8289 - 8298
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Route3
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335030-68-7 - ~%
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In-stock
51856-25-8
References
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Venable, Jennifer D.; Cai, Hui; Chai, Wenying; Dvorak, Curt A.; Grice, Cheryl A.; Jablonowski, Jill A.; Shah, Chandra R.; Kwok, Annette K.; Ly, Kiev S.; Pio, Barbara; Wei, Jianmei; Desai, Pragnya J.; Jiang, Wen; Nguyen, Steven; Ling, Ping; Wilson, Sandy J.; Dunford, Paul J.; Thurmond, Robin L.; Lovenberg, Timothy W.; Karlsson, Lars; Carruthers, Nicholas I.; Edwards, James P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8289 - 8298
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 53.09
- LogP 1.9276
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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