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CS-W001157 4
Total: USD 88.00

TCEP hydrochloride

  • CAS No. 51805-45-9

  • Cat. No. CS-W012216
  • Purity≥97%
  • MDL No.MFCD00145469

*For research and further manufacturing use only, not for direct human use.

TCEP hydrochloride|CS-W012216

Structure of 51805-45-9

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General Information

  • CAS No. 51805-45-9
  • Cat. No. CS-W012216
  • Purity ≥97%
  • MDL No. MFCD00145469
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₆ClO₆P
  • Molecular Weight 286.65
  • Synonym(s) Tris(2-​carboxyethyl)​phosphine hydrochloride
  • SMILES O=C(O)CCP(CCC(O)=O)CCC(O)=O.Cl

Description

Reducing persistent water-soluble disulfides at pH 4.5 within five minutes, Tris(2-carboxyethyl)phosphine hydrochloride solution (CAS 51805-45-9) maintains reductive potency across pH 1.5–8.5 and resists air oxidation more effectively than DTT.

Application

Tris(2-carboxyethyl)phosphine hydrochloride (CAS 51805-45-9) drives peptide and protein desulfurization by enabling efficient diboron-mediated transformations in complex reaction systems. It stabilizes thiol groups under physiological conditions. Researchers leverage this property to enhance thiol-Michael additions in electrospun scaffolds, improve sperm head lysis for RNA isolation, enable chiral cystine differentiation via peroxidase-mimicking assays, and boost accuracy in in situ cell digestion for proteomics workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   111.9
  • LogP   1.3142
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   9

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