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(3-Chloro-2-fluorophenyl)hydrazine hydrochloride

  • CAS No. 517920-75-1

  • Cat. No. CS-0063178
  • Purity≥97%
  • MDL No.MFCD03094280

*For research and further manufacturing use only, not for direct human use.

(3-Chloro-2-fluorophenyl)hydrazine hydrochloride|CS-0063178

Structure of 517920-75-1

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General Information

  • CAS No. 517920-75-1
  • Cat. No. CS-0063178
  • Purity ≥97%
  • MDL No. MFCD03094280
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇Cl₂FN₂
  • Molecular Weight 197.04
  • Synonym(s) 3-Chloro-2-fluorophenylhydrazine hydrochloride
  • SMILES [H]Cl.NNC1=CC=CC(Cl)=C1F

Description

(3-Chloro-2-fluorophenyl)hydrazine hydrochloride is a bench-stable, moisture-tolerant hydrazine derivative featuring a fluorinated aromatic core. This electron-deficient arylhydrazine integrates readily into heterocyclic syntheses, enabling efficient access to pharmacologically relevant triazoles and pyrazoles under mild conditions.

Application

(3-Chloro-2-fluorophenyl)hydrazine hydrochloride serves as a key building block for the synthesis of fluorinated heterocycles and azo dyes. Its well-established reactivity enables efficient cyclization and coupling reactions under standard conditions, with good bench stability and ease of purification. Functions as a versatile intermediate in medicinal chemistry and agrochemical research, particularly for constructing biologically relevant scaffolds via hydrazone formation and subsequent transformations.

Synthesis

  • Route1
    • 3-Chloro-2-fluoroaniline hydrochloride|CS-0752936
      650578-82-8
    • ~%
    • In-stock
      (3-Chloro-2-fluorophenyl)hydrazine hydrochloride|CS-0063178
      517920-75-1

    References

    • US2007/27178 A1, ; Page/Page column 21 ; US 20070027178 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   2.1865
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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