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5-Bromo-3-(hydroxymethyl)benzyl alcohol

  • CAS No. 51760-22-6

  • Cat. No. CS-M2192
  • Purity≥98%
  • MDL No.MFCD00229250

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(hydroxymethyl)benzyl alcohol|CS-M2192

Structure of 51760-22-6

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General Information

  • CAS No. 51760-22-6
  • Cat. No. CS-M2192
  • Purity ≥98%
  • MDL No. MFCD00229250
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BrO₂
  • Molecular Weight 217.06
  • Synonym(s) (5-Bromo-1,3-phenylene)dimethanol
  • SMILES BrC1=CC(CO)=CC(CO)=C1

Description

5-Bromo-3-(hydroxymethyl)benzyl alcohol features a benzyl alcohol scaffold with bromine at the para position relative to the hydroxymethyl group, enabling selective functionalization. The hydroxymethyl moiety provides a reactive handle for derivatization, while the bromine facilitates cross-coupling reactions. This compound exhibits good stability under standard handling conditions and serves as a key intermediate in synthetic pathways requiring dual functionality.

Application

5-Bromo-3-(hydroxymethyl)benzyl alcohol serves as a versatile building block for the synthesis of functionalized aromatic scaffolds, enabling efficient incorporation of bromo and hydroxymethyl groups in sequential transformations. Its bench-stable nature and compatibility with standard coupling reactions facilitate straightforward derivatization for medicinal chemistry and materials applications.

Synthesis

  • Route1

    References

    • Hoffmann-La Roche Inc. Patent: US6617346 B1, 2003 ;
  • Route2

    References

    • TEIJIN LIMITED Patent: EP1460059 A1, 2004 ; Location in patent: Page 8 ;
  • Route3

    References

    • Catala, Laure; Turek, Philippe; Le Moigne, Jacques; De Cian, Andre; Kyritsakas, Nathalie Tetrahedron Letters, 2000 , vol. 41, # 7 p. 1015 - 1018

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.4337
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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