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CS-W001157 4
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4-Methoxybenzimidamide hydrochloride

  • CAS No. 51721-68-7

  • Cat. No. CS-0042893
  • Purity≥97%
  • MDL No.MFCD00466114

*For research and further manufacturing use only, not for direct human use.

4-Methoxybenzimidamide hydrochloride|CS-0042893

Structure of 51721-68-7

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General Information

  • CAS No. 51721-68-7
  • Cat. No. CS-0042893
  • Purity ≥97%
  • MDL No. MFCD00466114
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClN₂O
  • Molecular Weight 186.64
  • Synonym(s) 4-Methoxybenzamidine hydrochloride
  • SMILES N=C(C1=CC=C(C=C1)OC)N.[H]Cl

Description

4-Methoxybenzimidamide hydrochloride is a bench-stable, moisture-tolerant heterocyclic compound featuring a methoxy-substituted benzimidamide core. This derivative delivers enhanced solubility in aqueous and polar organic media, enabling efficient integration into synthetic workflows for pharmaceutical intermediates and bioactive molecule scaffolds.

Application

4-Methoxybenzimidamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of benzimidazole-based scaffolds through straightforward coupling and cyclization reactions. Its stability under standard synthetic conditions and ease of purification facilitate integration into multi-step syntheses. The methoxy group enhances solubility and modulates electronic properties, while the imidamide functionality supports diverse derivatization pathways, making it a practical choice for developing bioactive heterocycles.

Synthesis

  • Route1

    References

    • Pischel, Helmut; Holy, Antonin; Wagner, Guenther Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 4 p. 933 - 940
  • Route2

    References

    • Moss, Robert A.; Terpinski, Jacek; Cox, D. Phillip; Denneey, Dorothy Z.; Krogh-Jespersen, Karsten Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2743 - 2748
  • Route3
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    • In-stock
      4-Methoxybenzimidamide hydrochloride|CS-0042893
      51721-68-7

    References

    • Moss, Robert A.; Terpinski, Jacek; Cox, D. Phillip; Denneey, Dorothy Z.; Krogh-Jespersen, Karsten Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2743 - 2748

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.1
  • LogP   1.40107
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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