Lot numbers can be found on the outside label of a product:
2-(3,5-Dichlorophenyl)acetic acid
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CAS No. 51719-65-4
- Cat. No. CS-W004733
- Purity≥98%
- MDL No.MFCD01764671
*For research and further manufacturing use only, not for direct human use.
Structure of 51719-65-4
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General Information
- CAS No. 51719-65-4
- Cat. No. CS-W004733
- Purity ≥98%
- MDL No. MFCD01764671
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₆Cl₂O₂
- Molecular Weight 205.04
- Synonym(s) benzeneacetic acid, 3,5-dichloro-; 2-(3,5-Dichlorophenyl)acetic acid
- SMILES C1=C(C=C(Cl)C=C1Cl)CC(O)=O
Description
This acetic acid derivative features a 3,5-dichlorophenyl substituent that imparts enhanced lipophilicity and metabolic stability. The carboxylic acid group enables direct coupling in peptide synthesis or conjugation workflows. Bench-stable and moisture-tolerant, it serves as a robust building block for bioactive molecule design.
Application
2-(3,5-Dichlorophenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard carboxylic acid transformations. Its electron-withdrawing dichlorophenyl moiety enhances metabolic stability and modulates lipophilicity, while the benzylic position offers facile functionalization. The compound exhibits good bench stability, ease of purification, and compatibility with common coupling protocols, making it well-suited for iterative synthetic campaigns targeting pharmaceutical intermediates and heterocyclic scaffolds.
Synthesis
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Route1
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In-stock
52516-37-7 - ~%
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In-stock
51719-65-4
References
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Wu, Jing; Tung, Jay S.; Thorsett, Eugene D.; Pleiss, Michael A.; Nissen, Jeffrey S.; Neitz, Jeffrey; Latimer, Lee H.; John, Varghese; Freedman, Stephen; Britton, Thomas C.; Audia, James A.; Reel, Jon K.; Mabry, Thomas E.; Dressman, Bruce A.; Cwi, Cynthia L.; Droste, James J.; Henry, Steven S.; McDaniel, Stacey L.; Scott, William Leonard; Stucky, Russell D.; Porter, Warren J. Patent: US2002/45747 A1, 2002 ;
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Route2
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201230-82-2 -
In-stock
7778-01-0 - ~%
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In-stock
51719-65-4
References
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TANABE SEIYAKU CO., LTD. Patent: WO2006/30984 A1, 2006 ; Location in patent: Page/Page column 63-64; 134 ; WO 2006/030984 A1
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Route3
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In-stock
52516-37-7
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7732-18-5
- ~%
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In-stock
51719-65-4
References
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Athena Neurosciences, Inc.; Eli Lilly and Company Patent: US6117901 A1, 2000 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 37.3
- LogP 2.6205
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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