Lot numbers can be found on the outside label of a product:
4-Chloropyrido[3,2-d]pyrimidine
-
CAS No. 51674-77-2
- Cat. No. CS-W022165
- Purity≥97%
- MDL No.MFCD10566748
*For research and further manufacturing use only, not for direct human use.
![4-Chloropyrido[3,2-d]pyrimidine|CS-W022165](https://file.chemscene.com/productPIC/CS-W022165.gif)
Structure of 51674-77-2
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 51674-77-2
- Cat. No. CS-W022165
- Purity ≥97%
- MDL No. MFCD10566748
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₄ClN₃
- Molecular Weight 165.58
- Synonym(s) pyrido[3,2-d]pyrimidine, 4-chloro-
- SMILES ClC1=NC=NC2=CC=CN=C12
Description
4-Chloropyrido[3,2-d]pyrimidine serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at the 4-position that enables direct functionalization. This electron-deficient system integrates readily into kinase inhibitors and other bioactive molecules, offering high reactivity under standard coupling conditions.
Application
4-Chloropyrido[3,2-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and other bioactive heterocycles. Its chlorine substituent facilitates palladium-catalyzed cross-coupling reactions, while the fused pyridopyrimidine core offers enhanced metabolic stability and predictable binding interactions. The compound exhibits excellent bench stability and compatibility with common protecting group strategies, facilitating straightforward purification and integration into multi-step synthetic sequences.
Synthesis
-
Route1
-
In-stock
![Pyrido[3,2-d]pyrimidin-4(3H)-one|CS-0037690](https://file.chemscene.com/productPIC/CS-0037690.gif)
37538-67-3 - ~%
-
In-stock
51674-77-2
References
-
Petric, Andrej; Tisler, M.; Stanovnik, Branko Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
-
-
Route2
-
In-stock
93683-65-9 - ~%
-
In-stock
51674-77-2
References
-
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A. Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
-
-
Route3
-
In-stock
171178-21-5 - ~%
-
In-stock
51674-77-2
References
-
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A. Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 38.67
- LogP 1.6782
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 4-Chloropyrido[3,2-d]pyrimidine sigma4-Chloropyrido[3,2-d]pyrimidine manufacturer4-Chloropyrido[3,2-d]pyrimidine price4-Chloropyrido[3,2-d]pyrimidine structure4-Chloropyrido[3,2-d]pyrimidine SDSbuy 4-Chloropyrido[3,2-d]pyrimidine4-Chloropyrido[3,2-d]pyrimidine supplier4-Chloropyrido[3,2-d]pyrimidine uses4-Chloropyrido[3,2-d]pyrimidine molecular weightprice of 4-Chloropyrido[3,2-d]pyrimidine4-Chloropyrido[3,2-d]pyrimidine chemical name formula of 4-Chloropyrido[3,2-d]pyrimidine