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CS-W001157 4
Total: USD 88.00

6-Ethylpyrimidine-2,4-diamine

  • CAS No. 514854-12-7

  • Cat. No. CS-0045755
  • Purity≥97%
  • MDL No.MFCD02091119

*For research and further manufacturing use only, not for direct human use.

6-Ethylpyrimidine-2,4-diamine|CS-0045755

Structure of 514854-12-7

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General Information

  • CAS No. 514854-12-7
  • Cat. No. CS-0045755
  • Purity ≥97%
  • MDL No. MFCD02091119
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀N₄
  • Molecular Weight 138.17
  • Synonym(s) 6-Ethyl-pyrimidine-2,4-diyldiamine
  • SMILES CCC1=NC(N)=NC(N)=C1

Description

6-Ethylpyrimidine-2,4-diamine features a pyrimidine core functionalized with two diamino groups and a C2 alkyl substituent, offering enhanced solubility and reactivity in synthetic transformations. This electron-rich scaffold enables efficient coupling reactions under mild conditions, facilitating the construction of complex heterocyclic architectures in medicinal chemistry and materials science applications.

Application

6-Ethylpyrimidine-2,4-diamine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds prevalent in kinase inhibitors and antiviral agents. Its two diamino groups facilitate diverse functionalization via alkylation, acylation, or coupling reactions, while the ethyl substituent enhances lipophilicity and metabolic stability. The compound exhibits good bench stability and is amenable to standard purification methods, supporting its use in multi-step synthesis and process development.

Synthesis

  • Route1
    • In-stock
      4-Chloro-6-ethylpyrimidin-2-amine|CS-W022155
      5734-67-8
    • null|null
      64-17-5
    • ~%
    • In-stock
      6-Ethylpyrimidine-2,4-diamine|CS-0045755
      514854-12-7

    References

    • Todd et al. Journal of the Chemical Society, 1936 , p. 1557 Full Text Show Details Huber; Hoelscher Chemische Berichte, 1938 , vol. 71, p. 87,99
  • Route2

    References

    • Richardson, Marianne L.; Stevens, Malcolm F.G. Journal of Chemical Research - Part S, 2002 , # 10 p. 482 - 484
  • Route3

    References

    • Richardson, Marianne L.; Stevens, Malcolm F.G. Journal of Chemical Research - Part S, 2002 , # 10 p. 482 - 484

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   77.82
  • LogP   0.2034
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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