Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Chloronicotinonitrile

  • CAS No. 51269-82-0

  • Cat. No. CS-W023127
  • Purity≥98%
  • MDL No.MFCD03411334

*For research and further manufacturing use only, not for direct human use.

5-Chloronicotinonitrile|CS-W023127

Structure of 51269-82-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 51269-82-0
  • Cat. No. CS-W023127
  • Purity ≥98%
  • MDL No. MFCD03411334
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClN₂
  • Molecular Weight 138.55
  • Synonym(s) 5-chloropyridine-3-carbonitrile
  • SMILES Clc1cncc(c1)C#N

Description

5-Chloronicotinonitrile features a chlorine atom at the 5-position of a pyridine ring, paired with a nitrile group at the 3-position. This electron-deficient heterocycle serves as a key building block in agrochemical and pharmaceutical synthesis, offering enhanced reactivity for nucleophilic substitution and coupling reactions under standard conditions.

Application

5-Chloronicotinonitrile serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized pharmaceutical intermediates. Its dual functionality—electrophilic chlorine and electron-withdrawing nitrile group—facilitates nucleophilic substitution, palladium-catalyzed coupling reactions, and regioselective derivatization. The compound exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis campaigns in medicinal chemistry and process development.

Synthesis

  • Route1
    • 3,5-Dichloropyridine Etoricoxib  Impurity|CS-0229442
      2457-47-8
    • null|null
      544-92-3
    • ~21%
    • In-stock
      5-Chloronicotinonitrile|CS-W023127
      51269-82-0

    References

    • Player, Mark R.; Lu, Tianbao; Hu, Huaping; Zhu, Xizhen; Teleha, Christopher; Kreutter, Kevin Patent: US2007/225282 A1, 2007 ; Location in patent: Page/Page column 37 ; US 20070225282 A1
  • Route2

    References

    • Bhatti, Inayat A.; Busby, Reginald E.; Bin Mohamed, Murtedza; Parrick, John; Shaw, C. J. Granville Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3581 - 3585
  • Route3

    References

    • Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1431 - 1435

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.60668
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 5-Chloronicotinonitrile sigma5-Chloronicotinonitrile manufacturer5-Chloronicotinonitrile price5-Chloronicotinonitrile structure5-Chloronicotinonitrile SDSbuy 5-Chloronicotinonitrile5-Chloronicotinonitrile supplier5-Chloronicotinonitrile uses5-Chloronicotinonitrile molecular weightprice of 5-Chloronicotinonitrile5-Chloronicotinonitrile chemical name formula of 5-Chloronicotinonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label