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CS-W001157 4
Total: USD 88.00

Thiophene-3-sulfonyl chloride

  • CAS No. 51175-71-4

  • Cat. No. CS-W019486
  • Purity≥97%
  • MDL No.MFCD02682011
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Thiophene-3-sulfonyl chloride|CS-W019486

Structure of 51175-71-4

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Description

Thiophene-3-sulfonyl chloride serves as a reactive electrophilic synthon for introducing sulfonamide functionalities in medicinal chemistry and materials synthesis. The thiophene ring imparts electron-rich character, enhancing conjugation in downstream architectures. This reagent features high functional group tolerance and operates reliably under standard anhydrous conditions, enabling efficient coupling with amines to yield stable sulfonamides.

Application

Thiophene-3-sulfonyl chloride serves as a versatile building block for sulfonamide and sulfone synthesis, enabling efficient incorporation of the thiophene ring into bioactive molecules. Its reactivity facilitates direct coupling with amines and alcohols under mild conditions, offering high functional group tolerance and bench stability. The molecule functions as a key scaffold component in medicinal chemistry and materials science applications.

General Information

  • CAS No. 51175-71-4
  • Cat. No. CS-W019486
  • Purity ≥97%
  • MDL No. MFCD02682011
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃ClO₂S₂
  • Molecular Weight 182.65
  • Synonym(s) Thiophene-3-sulphonyl chloride
  • SMILES O=S(C1=CSC=C1)(Cl)=O

Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.6756
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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