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3-(Piperidin-4-yl)propanoic acid hydrochloride

  • CAS No. 51052-79-0

  • Cat. No. CS-0012637
  • Purity≥95%
  • MDL No.MFCD06202371

*For research and further manufacturing use only, not for direct human use.

3-(Piperidin-4-yl)propanoic acid hydrochloride|CS-0012637

Structure of 51052-79-0

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General Information

  • CAS No. 51052-79-0
  • Cat. No. CS-0012637
  • Purity ≥95%
  • MDL No. MFCD06202371
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆ClNO₂
  • Molecular Weight 193.67
  • Synonym(s) 4-Piperidinepropanoic acid, hydrochloride
  • SMILES O=C(O)CCC1CCNCC1.Cl

Description

This piperidinylpropanoic acid derivative features a hydrophilic carboxylic acid group paired with a basic piperidine ring, enabling strong solubility in aqueous media. The hydrochloride salt form enhances stability and handling under standard bench conditions, facilitating integration into peptide conjugation and medicinal chemistry workflows.

Application

3-(Piperidin-4-yl)propanoic acid hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard amide coupling and functional group manipulation. Its piperidine-containing side chain provides favorable solubility and metabolic stability, while the carboxylic acid functionality facilitates direct conjugation or derivatization. The hydrochloride salt enhances bench stability and crystallinity, simplifying handling and purification in high-throughput screening campaigns and process development workflows.

Synthesis

  • Route1

    References

    • Novo Nordisk A/S Patent: US6040318 A1, 2000 ;
  • Route2

    References

    • Cohen, Judith H.; Roessler, Armin; Scott, Lorraine; Sorgi, Kirk L.; Villani Jr., Frank J.; Webster, Robin R. H.; Weh, Christian; Bos, Mary Ellen; Cesco-Cancian, Sergio; Harris, Bruce D.; Hortenstine, John T.; Justus, Michael; Maryanoff, Cynthia A.; Mills, John; Muller, Stefan Organic Process Research and Development, 2003 , vol. 7, # 6 p. 866 - 872
  • Route3
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      167414-86-0
    • ~%
    • In-stock
      3-(Piperidin-4-yl)propanoic acid hydrochloride|CS-0012637
      51052-79-0

    References

    • Froelund, Bente; Kristiansen, Uffe; Brehm, Lotte; Hansen, Annette B.; Krogsgaard-Larsen, Povl; Falch, Erik Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3287 - 3296

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   1.2726
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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