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CS-W001157 4
Total: USD 88.00

4-Piperidineacetic acid

  • CAS No. 51052-78-9

  • Cat. No. CS-W002877
  • Purity≥97%
  • MDL No.MFCD02093097

*For research and further manufacturing use only, not for direct human use.

4-Piperidineacetic acid|CS-W002877

Structure of 51052-78-9

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General Information

  • CAS No. 51052-78-9
  • Cat. No. CS-W002877
  • Purity ≥97%
  • MDL No. MFCD02093097
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₂
  • Molecular Weight 143.18
  • Synonym(s) 4-Piperidinylacetic acid
  • SMILES OC(=O)CC1CCNCC1

Description

4-Piperidineacetic acid features a piperidine ring fused to a carboxylic acid side chain, offering a balanced combination of basicity and solubility. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds where enhanced membrane permeability and metabolic stability are required. The molecule's amine functionality facilitates conjugation and derivatization under mild conditions.

Synthesis

  • Route1

    References

    • Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
  • Route2

    References

    • Karl Thomae Patent: US5994356 A1, 1999 ;
  • Route3

    References

    • Monovich, Lauren G.; Tommasi, Ruben A.; Fujimoto, Roger A.; Blancuzzi, Vincent; Clark, Kirk; Cornell, Wendy D.; Doti, Robert; Doughty, John; Fang, James; Farley, David; Fitt, John; Ganu, Vishwas; Goldberg, Ronald; Goldstein, Robert; Lavoie, Stacey; Kulathila, Raviraj; Macchia, William; Parker, David T.; Melton, Richard; O'Byrne, Elizabeth; Pastor, Gary; Pellas, Theodore; Quadros, Elizabeth; Reel, Noela; Roland, Dennis M.; Sakane, Yumi; Singh, Hem; Skiles, Jerry; Somers, Joseph; Toscano, Karen; Wigg, Andrew; Zhou, Siyuan; Zhu, Lijuan; Shieh, Wen-Chung; Xue, Song; McQuire, Leslie W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3523 - 3538

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.4607
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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