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Structure of 5100-98-1
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3-Chloro-2-iodotoluene features a strategically positioned chloro and iodo substituent on the toluene ring, enabling directed metalation and cross-coupling reactions. The electron-deficient aryl iodide facilitates efficient palladium-catalyzed transformations, while the ortho-chloro group enhances regioselectivity in subsequent functionalizations. This bench-stable derivative serves as a key intermediate in the synthesis of complex aromatic scaffolds.
3-Chloro-2-iodotoluene serves as a versatile biaryl coupling precursor in palladium-catalyzed cross-coupling reactions. The ortho-iodo group enables efficient Suzuki, Stille, and Negishi couplings, while the meta-chloro substituent offers orthogonal reactivity for sequential functionalization. Its bench-stable nature and compatibility with standard reaction conditions facilitate reliable synthesis of substituted arenes and complex heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: