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CS-W001157 4
Total: USD 88.00

Procainamide

  • CAS No. 51-06-9

  • Cat. No. CS-W009100
  • Purity≥95%
  • MDL No.MFCD00066880

*For research and further manufacturing use only, not for direct human use.

Procainamide|CS-W009100

Structure of 51-06-9

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General Information

  • CAS No. 51-06-9
  • Cat. No. CS-W009100
  • Purity ≥95%
  • MDL No. MFCD00066880
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁N₃O
  • Molecular Weight None
  • Synonym(s) Procaine amide; SP 100
  • SMILES O=C(NCCN(CC)CC)C1=CC=C(N)C=C1

Description

Procainamide delivers reliable antiarrhythmic activity through selective sodium channel blockade, offering sustained efficacy in managing ventricular arrhythmias. This well-characterized compound features a stable aromatic amine core and a hydrolytically resistant ester linkage, enabling consistent performance under standard physiological conditions.

Application

Procainamide serves as a clinically relevant aminoamide scaffold with established utility in medicinal chemistry. It functions as a key building block for analog synthesis, particularly in the development of antiarrhythmic agents and heterocyclic derivatives. The molecule exhibits robust bench stability and compatible functional group tolerance, enabling straightforward derivatization via amide coupling, electrophilic substitution, and reductive amination. Its structural motif facilitates incorporation into complex molecular architectures under standard synthetic conditions.

Synthesis

  • Route1
    • N-(2-(Diethylamino)Ethyl)-4-nitrobenzamide|CS-0767813
      1664-52-4
    • ~93%
    • In-stock
      Procainamide|CS-W009100
      51-06-9

    References

    • Kelly, Sean M.; Lipshutz, Bruce H. Organic Letters, 2014 , vol. 16, # 1 p. 98 - 101
  • Route2

    References

    • JANSSEN PHARMACEUTICA N.V. Patent: WO2006/74984 A1, 2006 ; Location in patent: Page/Page column 42 ; WO 2006/074984 A1
  • Route3
    • null|null
      122-04-3
    • ~%
    • In-stock
      Procainamide|CS-W009100
      51-06-9

    References

    • Iwaya; Yoshida Shionogi Kenkyusho Nenpo, 1952 , # 2 p. 114 Chem.Abstr., 1957 , p. 10424

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   58.36
  • LogP   1.3404
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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