Fmoc-(R)-3-amino-3-(4-nitrophenyl)-propionic acid

Name: Fmoc-(R)-3-amino-3-(4-nitrophenyl)-propionic acid
Brand: ChemScene
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CAS No. 507472-26-6
Cat. No. CS-0182707
Purity≥97%
MDL No.MFCD03428008

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Fmoc-(R)-3-amino-3-(4-nitrophenyl)-propionic acid|CS-0182707

Structure of 507472-26-6

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General Information

CAS No. 507472-26-6
Cat. No. CS-0182707
Purity ≥97%
MDL No. MFCD03428008
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀N₂O₆
Molecular Weight 432.43
Synonym(s) Fmoc-R-3-Amino-3-(4-nitro-phenyl)-propionic acid
SMILES OC(C[C@H](C1=CC=C(C=C1)[N+]([O-])=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O

Description

Fmoc-(R)-3-amino-3-(4-nitrophenyl)-propionic acid is a bench-stable, moisture-tolerant building block for peptide synthesis. This amino acid derivative features a para-nitrophenyl group that enhances solubility and facilitates purification via chromatography. The Fmoc protection enables efficient N-terminal capping during solid-phase workflows.

Application

Fmoc-(R)-3-amino-3-(4-nitrophenyl)propionic acid serves as a versatile building block for peptide synthesis and bioconjugation, enabling the incorporation of electron-deficient aromatic side chains. The Fmoc group ensures efficient orthogonal protection during solid-phase peptide synthesis, while the pendant 4-nitrophenyl moiety provides a handle for downstream derivatization via nucleophilic substitution. Its bench-stable nature and compatibility with standard coupling protocols facilitate reliable purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 118.77
LogP 4.6493
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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Fmoc-(R)-3-amino-3-(4-nitrophenyl)-propionic acid

CAS No. 507472-26-6

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