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CS-W001157 4
Total: USD 88.00

3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

  • CAS No. 507462-88-6

  • Cat. No. CS-0041441
  • Purity≥97%
  • MDL No.MFCD16994337

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol|CS-0041441

Structure of 507462-88-6

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General Information

  • CAS No. 507462-88-6
  • Cat. No. CS-0041441
  • Purity ≥97%
  • MDL No. MFCD16994337
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₉BO₄
  • Molecular Weight 250.10
  • Synonym(s) 4-Hydroxy-2-methoxyphenylboronic acid pinacol ester
  • SMILES OC1=CC=C(B2OC(C)(C)C(C)(C)O2)C(OC)=C1

Description

This boronate ester features a methoxy-substituted phenol scaffold, enabling direct coupling in Suzuki-Miyaura reactions. The tetramethyl-1,3,2-dioxaborolan-2-yl group provides enhanced stability and compatibility under standard conditions. Designed for efficient cross-coupling workflows, this reagent integrates seamlessly into synthetic sequences requiring precise functional group placement.

Application

3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol serves as a versatile boronate building block in Suzuki-Miyaura cross-coupling reactions. Its ortho-methoxy group enhances solubility and modulates reactivity, while the stable pinacol boronate moiety enables efficient coupling with aryl and vinyl halides under mild conditions. The compound exhibits excellent bench stability, simplifies purification, and is widely used in the construction of biaryl scaffolds for pharmaceutical and materials applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.92
  • LogP   1.7
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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