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CS-W001157 4
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Tetrahydro-2H-pyran-4-carbaldehyde

  • CAS No. 50675-18-8

  • Cat. No. CS-D1228
  • Purity≥95%
  • MDL No.MFCD03425264

*For research and further manufacturing use only, not for direct human use.

Tetrahydro-2H-pyran-4-carbaldehyde|CS-D1228

Structure of 50675-18-8

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General Information

  • CAS No. 50675-18-8
  • Cat. No. CS-D1228
  • Purity ≥95%
  • MDL No. MFCD03425264
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) Tetrahydro-pyran-4-carbaldehyde
  • SMILES O=CC1CCOCC1

Description

Tetrahydro-2H-pyran-4-carbaldehyde features a stable, moisture-tolerant tetrahydropyran ring with a reactive aldehyde handle at the 4-position. This configuration enables direct integration into complex molecular architectures, particularly in glycosylation and polyether synthesis. The aldehyde group supports efficient coupling under mild conditions, offering predictable reactivity in multi-step transformations.

Application

Tetrahydro-2H-pyran-4-carbaldehyde serves as a versatile synthon in organic synthesis, enabling efficient construction of oxygen-containing heterocycles and functionalized aliphatic chains. Its aldehyde functionality exhibits excellent compatibility with nucleophilic additions, reductive amination, and coupling reactions under mild conditions. The tetrahydropyran ring provides stereochemical control and enhanced metabolic stability, making it a valuable building block for complex molecular architectures in medicinal chemistry and natural product synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   0.6119
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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