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CS-W001157 4
Total: USD 88.00

1-Methyl-1H-benzo[d]imidazol-5-ol

  • CAS No. 50591-22-5

  • Cat. No. CS-0043996
  • Purity≥97%
  • MDL No.MFCD00456136

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-benzo[d]imidazol-5-ol|CS-0043996

Structure of 50591-22-5

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General Information

  • CAS No. 50591-22-5
  • Cat. No. CS-0043996
  • Purity ≥97%
  • MDL No. MFCD00456136
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 1H-Benzimidazol-5-ol,1-methyl-(9CI)
  • SMILES OC1=CC=C2N(C)C=NC2=C1

Description

1-Methyl-1H-benzo[d]imidazol-5-ol features a fused heterocyclic core with a methylated imidazole ring and a phenolic hydroxyl group, delivering enhanced solubility and stability under standard conditions. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor development and fluorescent probe engineering.

Application

1-Methyl-1H-benzo[d]imidazol-5-ol serves as a versatile heterocyclic building block in medicinal chemistry, offering a stable, bench-compatible scaffold for derivatization at the C5 position. Its phenolic hydroxyl group enables facile functionalization via etherification, esterification, or transition-metal-catalyzed coupling reactions. The methylated imidazole core provides enhanced metabolic stability and favorable solubility profiles, making it suitable for the synthesis of bioactive compounds and pharmaceutical intermediates.

Synthesis

  • Route1
    • 4-Ethoxy-N-methyl-2-nitrobenzenamine|CS-0326862
      61679-18-3
    • ~%
    • In-stock
      1-Methyl-1H-benzo[d]imidazol-5-ol|CS-0043996
      50591-22-5

    References

    • Friedrich; Bernhauer Chemische Berichte, 1956 , vol. 89, p. 2030,2038
  • Route2
    • null|null
      97302-32-4
    • ~%
    • In-stock
      1-Methyl-1H-benzo[d]imidazol-5-ol|CS-0043996
      50591-22-5

    References

    • Friedrich; Bernhauer Chemische Berichte, 1956 , vol. 89, p. 2030,2038
  • Route3
    • null|null
      97953-31-6
    • ~%
    • In-stock
      1-Methyl-1H-benzo[d]imidazol-5-ol|CS-0043996
      50591-22-5

    References

    • Friedrich; Bernhauer Chemische Berichte, 1956 , vol. 89, p. 2030,2038

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.2789
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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