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Structure of 505084-58-2
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This pyridinecarboxylic acid features a chlorine substituent at the 2-position and a trifluoromethyl group at the 5-position, creating a highly electron-deficient heterocyclic core. The carboxylic acid functionality enables direct coupling reactions in synthetic sequences. This combination delivers enhanced stability and reactivity for applications in medicinal chemistry and agrochemical synthesis.
2-Chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group and a halogenated pyridine core into complex scaffolds. Its carboxylic acid functionality facilitates amide coupling and esterification reactions under standard conditions, while the chlorine and trifluoromethyl groups offer orthogonal reactivity for cross-coupling and functionalization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: