2-Chloro-3-fluorobenzenesulfonyl chloride

Name: 2-Chloro-3-fluorobenzenesulfonyl chloride
Brand: ChemScene
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CAS No. 504424-79-7
Cat. No. CS-0610046
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-3-fluorobenzenesulfonyl chloride|CS-0610046

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General Information

CAS No. 504424-79-7
Cat. No. CS-0610046
Purity ≥95%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃Cl₂FO₂S
Molecular Weight 229.06
Synonym(s) 2-Chloro-3-fluorobenzene-1-sulfonyl chloride
SMILES O=S(C1=CC=CC(F)=C1Cl)(Cl)=O

Description

2-Chloro-3-fluorobenzenesulfonyl chloride features a dual halogenated aromatic ring paired with a reactive sulfonyl chloride group, enabling selective sulfonation in complex molecule synthesis. This bench-stable reagent facilitates efficient incorporation of sulfonate moieties under mild conditions, offering high functional group tolerance and clean reaction profiles in pharmaceutical and agrochemical development workflows.

Application

2-Chloro-3-fluorobenzenesulfonyl chloride serves as a versatile electrophilic sulfonylating agent, enabling efficient introduction of the sulfonyl group into aromatic and heterocyclic systems. Its reactivity is enhanced by the electron-withdrawing chlorine and fluorine substituents, which stabilize the intermediate and improve selectivity in nucleophilic substitution. The compound exhibits good bench stability and facilitates clean reactions with amines and alcohols, making it valuable for synthesizing sulfonamide and sulfonate derivatives used in medicinal chemistry and agrochemical research.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 2.4066
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-3-fluorobenzenesulfonyl chloride

CAS No. 504424-79-7

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