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CS-W001157 4
Total: USD 88.00

3-Hydroxypyridazine

  • CAS No. 504-30-3

  • Cat. No. CS-D0990
  • Purity≥97%
  • MDL No.MFCD00099605

*For research and further manufacturing use only, not for direct human use.

3-Hydroxypyridazine|CS-D0990

Structure of 504-30-3

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General Information

  • CAS No. 504-30-3
  • Cat. No. CS-D0990
  • Purity ≥97%
  • MDL No. MFCD00099605
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄N₂O
  • Molecular Weight 96.09
  • Synonym(s) 3-Pyridazinol; 3-Pyridazinone; 6-Pyridazinone; Pyridazin-3(2H)-one
  • SMILES O=C1C=CC=NN1

Description

3-Hydroxypyridazine is a bench-stable heterocyclic compound featuring a hydroxyl group at the 3-position of the pyridazine ring. This functionalization enhances solubility and enables direct participation in hydrogen-bonding interactions, facilitating its use in synthetic transformations and as a building block for bioactive molecules.

Application

3-Hydroxypyridazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position via esterification, amidation, or metal-catalyzed coupling reactions. Its moderate stability under ambient conditions and compatibility with common protecting group strategies facilitate efficient synthesis of pyridazine-based heterocycles. The hydroxyl group provides a handle for derivatization while maintaining good solubility and chromatographic behavior, making it well-suited for iterative synthesis campaigns and lead optimization workflows.

Synthesis

  • Route1
    • null|null
      1173165-19-9
    • ~85%
    • In-stock
      3-Hydroxypyridazine|CS-D0990
      504-30-3

    References

    • Donohoe, Timothy J.; Fishlock, Lisa P.; Basutto, Jose A.; Bower, John F.; Procopiou, Panayiotis A.; Thompson, Amber L. Chemical Communications, 2009 , # 21 p. 3008 - 3010
  • Route2
    • null|null
      110-89-4
    • null|null
      60-29-7
    • null|null
      106-89-8
    • null|null
      56872-17-4
    • ~48%
    • In-stock
      3-Hydroxypyridazine|CS-D0990
      504-30-3
    • null|null
      56872-18-5

    References

    • Smith Kline and French Laboratories, Inc. Patent: US3931177 A1, 1976 ; US 3931177 A
  • Route3
    • null|null
      75-44-5
    • null|null
      145743-48-2
    • ~%
    • In-stock
      3-Hydroxypyridazine|CS-D0990
      504-30-3
    • WAY127093B racemate|CS-6557
      145743-63-1

    References

    • American Home Products Corporation Patent: US5191084 A1, 1993 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   -0.2301
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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