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CS-W001157 4
Total: USD 88.00

(6-Methoxy-4-methylpyridin-3-yl)boronic acid

  • CAS No. 503184-35-8

  • Cat. No. CS-0175836
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(6-Methoxy-4-methylpyridin-3-yl)boronic acid|CS-0175836

Structure of 503184-35-8

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General Information

  • CAS No. 503184-35-8
  • Cat. No. CS-0175836
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀BNO₃
  • Molecular Weight 166.97
  • Synonym(s) 6-Methoxy-4-methylpyridin-3-ylboronic acid
  • SMILES CC1=CC(OC)=NC=C1B(O)O

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized heterocycles with high efficiency. The methoxy and methyl substituents enhance solubility and stability, while the pyridine core provides a rigid, electron-rich platform for further derivatization.

Application

(6-Methoxy-4-methylpyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The pyridine core provides orthogonal reactivity, while the methoxy and methyl groups enhance solubility and electronic tuning. Bench-stable and readily purified by recrystallization, it functions reliably in late-stage functionalization workflows.

Synthesis

  • Route1

    References

    • Arvanitis, Argyrios G; Arnold, Charles R; Fitzgerald, Lawrence W; Frietze, William E; Olson, Richard E; Gilligan, Paul J; Robertson, David W Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 289 - 291

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.92158
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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