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CS-W001157 4
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2,3-Dibromo-1,4-dimethoxybenzene

  • CAS No. 5030-61-5

  • Cat. No. CS-0061897
  • Molecule weight295.96
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,3-Dibromo-1,4-dimethoxybenzene|CS-0061897

Structure of 5030-61-5

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General Information

  • CAS No. 5030-61-5
  • Cat. No. CS-0061897
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈Br₂O₂
  • Molecular Weight 295.96
  • Synonym(s) 1,4-DIMETHOXY-2,3-DIBROMOBENZENE
  • SMILES COC1=C(C(=C(C=C1)OC)Br)Br

Description

2,3-Dibromo-1,4-dimethoxybenzene features two bromine atoms at adjacent positions on a benzene ring flanked by methoxy groups, enabling selective cross-coupling reactions. The electron-donating methoxy substituents enhance reactivity in palladium-catalyzed transformations while maintaining stability under standard conditions. This aryl dibromide serves as a key intermediate for constructing complex aromatic architectures in synthetic organic chemistry and materials science.

Application

2,3-Dibromo-1,4-dimethoxybenzene serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of substituted aromatic systems. The bromine atoms facilitate palladium-catalyzed coupling reactions such as Suzuki and Stille couplings, while the dimethoxy groups provide orthogonal protection and influence electronic properties. Its bench-stable nature and ease of purification make it well-suited for multi-step synthesis and scale-up applications.

Synthesis

  • Route1
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      1266379-51-4
    • null|null
      74-88-4
    • ~82%
    • In-stock
      2,3-Dibromo-1,4-dimethoxybenzene|CS-0061897
      5030-61-5

    References

    • Diemer, Vincent; Leroux, Frederic R.; Colobert, Fracoise European Journal of Organic Chemistry, 2011 , # 2 p. 327 - 340
  • Route2

    References

    • Diemer, Vincent; Leroux, Frederic R.; Colobert, Fracoise European Journal of Organic Chemistry, 2011 , # 2 p. 327 - 340
  • Route3
    • null|null
      1266379-46-7
    • ~%
    • In-stock
      2,3-Dibromo-1,4-dimethoxybenzene|CS-0061897
      5030-61-5

    References

    • Diemer, Vincent; Leroux, Frederic R.; Colobert, Fracoise European Journal of Organic Chemistry, 2011 , # 2 p. 327 - 340

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   3.2288
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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